When something gives you the creeps, it causes you to feel scared or uncomfortable.
Example: A big spider gives me the creeps.
creeps Informal A sensation of fear or repugnance, as if things were crawling on one's skin.
Note: "He gives me the creeps!", "He gives me the willies" (older saying, apparently dying), or "He creeps me out" are more casual forms. "He makes my skin crawl" is a fairly formal way to say the same.